2000-2013

The second tenure of Fr Varghese Anikuzhy S.J. as the Principal witnessed infrastructure development on a gigantic scale and at a brisk pace and also reaffirmed and improved upon the legacy of all-round excellence. Fr.Joseph Edasserry was in Loyola School as a teacher and Vice-Principal from 1993-2013.

The major additions and alterations to the infrastructure during this period are:
The first two floors of the CBSE wing, networking facility in the computer lab, Loyola Cricket Academy and fully equipped Multimedia Room open to all classes—all in 2002; the Children’s Park in 2003; the third floor of the CBSE block and five new science labs and a language lab there in 2007; the gigantic Indoor Stadium and the facelift to the main gate in 2009, asphalting all roads on the campus and concreting the basketball court on the Northern side in 2010; roofing and floor-tiling of the canteen-lounge-cum-waiting shed, the new RCC retention wall along the boundary on the stadium end, and five more buses that increased the fleet-strength to eleven—all in 2011; CCTV surveillance of the entire campus and the electronic display facility for daily news flash in 2012—all of these at the cost of a few crores.

Among the major changes during this period are: increasing the student-intake by gradually adding one more division to each class (which has resulted in almost doubling the student-strength from 900 in 1980 to about 1750 in 2012); starting the CBSE and HSE stream in 2002; the upgradation of the CBSE stream to the Senior Secondary level in 2008 and the experimental introduction of the Humanities section to the ISC stream in 2010.

2006 to 2010

Mr Thomaskutty M.T. had been the Principal of the CBSE School from 2006 to 2010.

2000-2001

Fr. Toby Joseph SJ who worked here in 2000-2001 rejoined the school as the Vice-Principal of the CBSE section in May 2008 and continued in that capacity till December 2010. The first major task he accomplished was preparing the CBSE labs for the first batch of senior secondary students. Also, he served as the nodal officer for the visit of Dr. APJ Abdul Kalam to the school.

Fr M.M. Thomas, S.J., who served Loyola School in various capacities for over 35 years, completed 50 years as a priest in March 2010. He arrived here in 1976, served as the Boarding Director, then as the Procurator, taught till 2000 and then served as the Vice Principal of the Junior School and at last as Assistant Manager of the CBSE section.

Among other memorable events and achievements of the period are: 'Back to School' becoming an unfailing annual programme, three senior Loyolites (Prasanth N., Vyasan R. and Anish Rajan) finding themselves among the Top 10 in the IAS Examination of 2007, the Fifth National Jesuit Alumni Congress on Loyola Campus in September 2007and Dr A. P. J. Abdul Kalam's visit on 24 July 2009. The year 2011 remains unforgettable for the grand celebration of the Golden Jubilee. The year-long celebrations were formally inaugurated by the Minister for Labour Shri Shibu Baby John on 4 June 2011. The highlights of celebrations were:

• The release of the Golden Jubilee logo by Padma Vibhushan Dr G. Madhavan Nair,
• The release of the Special Cover by the Chief Post Master General Mrs Shoba Koshy,
• The release of Magis, the docu-film on the birth and growth of the school,
• The Musical Night featuring playback singers Mr G. Venugopal and Mrs Jyotsna,
• The Technical Exhibition that brought together giants like ISRO, BSNL, the Indian Postal Department, CTCRI, CRPF, and the leading publishers,
• Inter-school and Intramural Exhibitions,
• Food Fair organized by the lady teachers,
• Guruvandanam organized by LOBA on 6 September
• Loyola Quest 2011, the All-Kerala Quiz competition organized by LOBA, and
• The release of Magis, the Golden Jubilee Souvenir, by H.E. Most Rev. Dr Joshua Ignathios in the concluding function presided over by Dr K.C. Dasgupta, Director of IIST, on 26 November.
• Fr Varghese Anikuzhy, S.J. stepped down on 20 May 2013 after his 13-year-long service as the Principal. Along with him the Vice Principal, Fr Joseph Edassery S. J., too, bid farewell